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Dietary and Hydration Changes : Many patients modify their eating and drinking habits when starting GLP-1 therapy

Eating a balanced mix of nutritious foods can help support healthy weight loss and maintain energy levels throughout the day

Are there strategies to minimize side effects while maintaining the approved dosing schedule, such as dietary modifications or anti-nausea medications

Author contributions KM and DW planned the experiments

37,39,40 To date, four PAC1R structures were reported, namely, PACAP38PAC1RG s (3.0 ), 20 PACAPPAC1Rmini-G s (3.9 ), 41 PACAP38PAC1RG s (3.5 ) 42 and maxadilanPAC1RG s (3.6 )

Key management considerations include: Continuing prescribed arthritis medications (disease-modifying agents, corticosteroids) as directed Monitoring for new or worsening joint symptoms that may require evaluation Maintaining adequate protein intake (generally 0.8-1.0 g/kg body weight, individualized based on age and kidney function) to preserve muscle mass during weight loss Ensuring sufficient calcium and vitamin D for bone health Reporting severe joint pain, swelling, or functional limitation promptly Patients should seek medical evaluation if they experience sudden onset of severe joint pain, joint swelling with redness or warmth, inability to bear weight, joint symptoms accompanied by fever, or persistent pain lasting more than 6 weeks