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Compared to 28.5% (1,071 patients) in the non-GLP-1 RA cohort
Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy
10.1186/s12888-023-05295-6 Summary Keywords ADHD, duration, insomnia, long-acting, side effects Citation Young JL, Powell RN, Powell A, Welling LLM, Granata L, Saal J, Nash M and Corliss M (2026) Real-world evaluation of attention deficit hyperactivity disorder symptoms and side effects in patients prescribed serdexmethylphenidate/dexmethylphenidate or other stimulants
Some of these use entirely different peptide structures that may be better suited to oral delivery
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