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In multiple pathological settings, affected cells are not distributed randomly, but instead form contiguous zones of degeneration, synchronized tubular epithelial loss, aligned myofiber injury, or expanding fronts of tissue damage, patterns that are difficult to reconcile with strictly cell-autonomous execution

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Moreover, L-carnitine co-administration confers partial nephroprotection in mice treated with colistin, without interfering with its pharmacokinetics and antibacterial activity

These findings establish the mechanistic basis for the compound and provide proof of concept for its metabolic effects

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