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Lower incidence of side effects and improved tolerability In clinical trials, 78.9% to 81.8% of patients using tirzepatide experienced side effects compared to 72% of participants in the placebo group

The sublingual route: the most realistic oral approach for tirzepatide Of all oral delivery methods, sublingual absorption remains the most pharmacologically plausible route for a large peptide like tirzepatide

While these symptoms are nonspecific, they may indicate hypomagnesemia, especially in patients with chronic diarrhea, malabsorption, or poorly controlled diabetes

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However, it is worth noting these improvements may reflect the physiologic consequences of rapid weight loss rather than reversal of underlying disease mechanisms, and whether such changes would persist without definitive obesity treatment is unknown

Our group recently published a peerreviewed case report in JCEM Case Reports describing an atypical retrobulbar optic neuropathy occurring shortly after semaglutide dose escalation