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To qualify for these medications, per the FDA, patients must have: BMI 30, or BMI 27 with at least one weight-related condition, such as high cholesterol, high blood pressure, or Type 2 diabetes Wegovy has also been approved as an oral tablet for patients who prefer not to use an injection
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In humans, Berberine positively impacts obesity by modulating gut microbiota diversity at doses as low as 500 mg/day and significantly improving cholesterol metabolism at 300 mg/day
To put that in perspective, the approved GLP-1 drugs achieved less weight loss in longer timeframes: for example, semaglutide (Wegovy) averages about 15% weight loss over ~16 months, and tirzepatide (Zepbound) achieved around 22.5% at 72 weeks in trials