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Subsequently, GLP-1s gained FDA approval for weight loss in 2014 (liraglutide: Saxenda/Victoza), 2021 (semaglutide: Wegovy/Ozempic/Rybelsus), and 2023 (tirzepatide: Zepbound/Mounjaro)
doi: 10.1046/J.1365-2230.2001.00817.X 172 BonettaR
Remember, reducing doses is a temporary strategy in a planned process
In the head-to-head DREAMS-3 study, glucagon/GLP-1 agonist mazdutide was more effective than GLP-1 agonist Ozempic (semaglutide) at reducing haemoglobin A1c levels, a marker for blood glucose control, and at helping subjects to lose weight