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Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)

Causes and considerations: Direct taste sensation from the copper-containing complex Post-nasal drip from nasal formulations Transient effect often mitigated with delivery technique adjustments The metallic taste is not typically a clinically meaningful adverse effect, but it can be bothersome enough that patients discontinue therapy

By now, body composition changes (reduced visceral fat, modest lean mass gain) may be measurable on DEXA if the clinician ordered a baseline scan

Disclosures from the last 36 months within and outside the submitted work: P.L.: none related to the current manuscript

References These statements have not been evaluated by the Food and Drug Administration (FDA)

Pelvic floor strengthening exercises (e.g., Kegel exercises) should be avoided