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Dark Skin Patches (Acanthosis Nigricans) Dark, velvety skin patches, usually on the neck, underarms, or groin, are linked to insulin resistance

These reactions are typically mild, self-limiting, and resolve without intervention

GLP-1s were designed to help manage blood sugar and glucose levels in people with type 2 diabetes

Nat Metab 8 , 559571 (2026)

Infiltrating CCR2 monocytes become pro-inflammatory macrophages, releasing NO, ROS, IL-1, and TNF-, which enhances microglial priming and causes mitochondrial stress in dopaminergic neurons

Because of this, light spotting or mild bruising may occasionally appear and is generally considered a minor local reaction during treatment with the Mounjaro pen