The available window for an agonist to produce a measurable increase is compressed, because half the signal is already spent, so a genuine agonist effect can look smaller than it is
Blood samples were collected at Baseline (Day 0), Day 3, and Day 7
10.1073/pnas.161300998 108 TiwariV.PatelM
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The increased risk of DKA in the SGLT2i group, and the associated hospitalisation, was not great enough to offset the increased rate of hospitalisation of any cause in the GLP-1 RA group
The presence of favourable reimbursement frameworks in the U.S