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Studies have indicated that when Ozempic (oral semaglutide) and levothyroxine are taken together, there can be a measurable increase in the total exposure to thyroid hormone (an increase in levothyroxines Area Under the Curve, or AUC, by approximately 33% in some trials)
Some of these lawsuits claim that taking Ozempic caused patients to suffer from unexpected gastrointestinal complications, including stomach paralysis and bowel obstructions, as well as pancreatitis and blood clots
Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W (1993) Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
This is one reason many obesity medicine experts now view these medications as long-term treatments rather than temporary interventions
Recent studies also suggest that genetics may play a role in determining individual response
Clin Gastroenterol Hepatol 2020
