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Fatigue is more prominent during the first few weeks of starting semaglutide, as the body adapts to the medication

10.1172/JCI176660 39 ZhangC.XieY.ChenH.LvL.YaoJ.ZhangM.et al (2020)

Semaglutide and tirzepatide are FDA-approved, orforglipron is under review, retatrutide remains in Phase 3 trials, and CagriSema has not been submitted