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[Ref] Psychiatric Acetaminophen (paracetamol)-diphenhydramine: Frequency not reported : Irritability, nervousness, anxiety, hallucinations, paradoxical excitation [Ref] Cardiovascular Acetaminophen (paracetamol): Frequency not reported : Hypotension Diphenhydramine: Frequency not reported : Hypotension, tachycardia, palpitations [Ref] Gastrointestinal Acetaminophen (paracetamol): Rare (less than 0.1%): Acute pancreatitis Diphenhydramine: Frequency not reported : Nausea, dry mouth, dyspepsia, constipation [Ref] Renal Acetaminophen (paracetamol): Rare (less than 0.1%): Acute tubular necrosis, interstitial nephritis [Ref] Acute tubular necrosis usually occurs in conjunction with liver failure, but has been observed as an isolated finding in rare cases

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