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The damaged mitochondria are engulfed and sequestered into autophagosomes, forming mitochondrial autophagosomes, which then fuse with lysosomes for degradation, ensuring the balance of mitochondrial content and energy [7]

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Some investigations have demonstrated that the two compounds, acting as agonists of the GSH antioxidant system, well prevent oxidative stress and reduce heart damage in some animal cardiomyopathy models, for instance, the ISO-induced myocardium infarction model [159, 160]

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