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A systematic review from Australias Hunter Medical Research Institute found that although diabetes and obesity drugs are linked to substantial weight loss, clinical trials have largely failed to report what people are actually eating while taking them. A reduction in body weight does not automatically mean a person is well-nourished or healthy, said Clare Collins, laureate professor of nutrition and dietetics at The University of Newcastle, in a press release

While the bupropion in Contrave helps reduce hunger and improve energy and mood, the naltrexone blocks certain opioid receptors involved in the brains reward response to food

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