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Comparator Selection: Full-length hGH (to demonstrate receptor-independent effects) -adrenergic agonists (to show distinct mechanism) Vehicle control 4

Due to change in size and shape, the movement of red blood cells from bone marrow to the bloodstream become ineffective, often leading to megaloblastic anemia

General Adverse Reactions: Headaches, fatigue, and dizziness are other common side effects

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There has been a great deal of interest in the link between elevated levels of homocysteine, a direct consequence of vitamin B 12 deficiency, and cardiovascular disease