Tirzepatide has a more established safety profile regarding heart health
did not find any significant changes of renin, aldosterone, and urinary angiotensinogen after a single GLP-1 infusion in healthy men 28 and the same result was reported in patients with diabetes without kidney function impairment 32
PCOS itself is an independent risk factor for prediabetes progression, and metformin carries a separate evidence base for metabolic improvement in that context
Effects of tirzepatide, a dual GIP and GLP-1 receptor agonist, on glucose-dependent insulin secretion and insulin sensitivity in adults with type 2 diabetes
In the country, approximately 18% of the population are on GLP-1s, according to doctors
10.1590/S1677-04202005000100003 9 FaziliI