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In plain English, men receiving testosterone were no more likely to suffer a heart attack, stroke or cardiovascular death than men receiving placebo

whereas cyanocobalamin does not have this effect (7)

Concomitant use of semaglutide with insulin or insulin secretagogues may result in hypoglycemia, and a dose reduction in the concomitant medication may be necessary

And the results of that trial were published last August (2017): Title: Exenatide once weekly versus placebo in Parkinsons disease: a randomised, double-blind, placebo-controlled trial Authors: Athauda D, Maclagan K, Skene SS, Bajwa-Joseph M, Letchford D, Chowdhury K, Hibbert S, Budnik N, Zampedri L, Dickson J, Li Y, Aviles-Olmos I, Warner TT, Limousin P, Lees AJ, Greig NH, Tebbs S, Foltynie T Journal: Lancet 2017 Aug 3

Interim Results from Ongoing Phase 2 COURAGE Trial Confirm Potential to Improve the Quality of Semaglutide-Induced Weight Loss. Press Release, June 2, 2025