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Its original characterisation used isolated amphibian and reptilian skin bioassays before the cloned human receptors were available, and those historic potency data remain the reason the compound is described as superpotent in the older literature

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Besides an increased homocysteine export from tissues into plasma that may be regulated by a reduced-homocysteine carrier (Blom, 2000), hyperhomocysteinemia can result from reduced renal function, which may have a central role in plasma homocysteine clearance, and from chronic hepatic insufficiency

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doi: 10.1093/ajcn/nqz160 16