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Serious adverse events were fewer in the semaglutide group (33.4% vs 36.4%), including cardiac disorders specifically (11.5% vs 13.5%)

Download our GLP-1 app to Turn Your Weight Loss Journey into Your Favorite Game Summary Diarrhea is a recognized semaglutide side effect, appearing in about 10% of patients in a 2025 Bayesian network meta-analysis and 10.6% in at least one cohort, so this side effect is measurable rather than rare complaints

Glick HA, Briggs AH, Polsky D

What the TRIUMPH 4 Phase 3 Data Actually Shows The phase 2 data that first made headlines reported approximately 24 percent body weight loss at 48 weeks

Phosphocreatine helps you make adenosine triphosphate (ATP), which is a source of energy your muscle cells need when you're active