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While medications maintain sustained, supraphysiologic hormone levels and typically produce significant weight reduction and HbA1c decreases, food-stimulated GLP-1 is released in brief pulses after meals and rapidly degraded within minutes, resulting in smaller metabolic improvements

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4452.pdb A homology structural built by Modeller [44] for the complex structure of GLP-1R ECD and semaglutide analogues with three site-specific missense mutations L23B R, I20B Q and V24B R