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Some clinical studies have found elevated lactate levels (395, 396) in ME/CFS patient blood, cerebrospinal fluid, and muscles, suggesting there is reduced oxidative phosphorylation and a switch to anaerobic glycolysis (392, 397399)
Additionally, in patients diagnosed with the CCC, the HLA types HLA-C*07:04 or HLA-DQB1*03:03 were shown to be significantly linked to ME/CFS status when using the CCC (89)
Furthermore, the combination of siFBXO22 and BPC157 did not yield additional effects (Fig
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