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A compensatory response resulting from an increased level of acetyl-carnitinewhich reflects cellular acetyl-CoA, a potent allosteric activator of PCwas reported in both INS-1 cells and isolated islets with moderately lowered PC [36]

Finally, we performed PheWAS to assess other phenotypes linked to these proteins, thereby providing insights into potential side effects associated with their roles as therapeutic targets

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doi: 10.1016/j.biopha.2020.110108 61 KobayashiSHamashimaSHommaTSatoMKusumiRBannaiSet al

Carnitine is vital for supplying the brain with energy by facilitating fatty acid transfer to cells and might also play a role in mood regulation