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Recent data from the ATTAIN-MAINTAIN trial showed that patients transitioning to orforglipron after injectable GLP-1 therapy maintained their weight loss with minimal regain (approximately 0.9 kg after semaglutide transition), suggesting that oral maintenance strategies could minimize the lean mass depletion seen with prolonged high-dose injectable therapy

This synergistic effect arises because a lowcalorie diet reduces fat intake, while it promotes lipolysis and energy expenditure, together achieving more efficient fat reduction and metabolic improvement

In comparison, the subcutaneously administered once-weekly semaglutide CVOT, SUSTAIN 6 has shown superiority over placebo with a significant 26% risk reduction for MACE [19]

PMID: 16840198

In: Feingold KR, Anawalt B, Boyce A, et al, eds