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In cutaneous melanomas, well-known differences exist in the biologic behaviors of the radial growth phasemelanoma (flat or macular), vertical growth phasemelanoma (mass, nodule, elevation), and vertical growth phasemelanoma with metastasis

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In some people, it can affect the tissues around the eyes, certain nerves, the meninges (the protective layers around the brain), or glands in the face and neck and that can lead to headaches, swelling, or eye problems