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These include the intrinsically low immunogenicity of tumor cells, systemic toxicities, and, most substantially, the profoundly immunosuppressive characteristics of the TME [15,16]
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As these combinations move toward approval, oral formulations may follow
28 Varela-EirnM.Carpintero-FernndezP.Snchez-TempranoA.Varela-VzquezA.PanoC
When administered following clinical assessment and appropriate dosing, IV B-complex is generally well tolerated
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