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As discussed, the anti-hyperglycaemic effects of DPP-4 inhibition are mediated via enhancing levels of endogenous DPP-4 substrates, since the inhibitors themselves do not possess any inherent glucose-lowering activity

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In 2023, an estimated 13.3 million Medicare beneficiaries enrolled in Parts A and B had obesity or overweight, based on having BMI of 27 or more recorded in claims or encounter data, or 24% of Medicare beneficiaries overall (Figure 1)

Patients and prescribers should be aware that whilst contraindications are relatively rare, gastrointestinal side effects such as nausea or vomiting, and restlessness have been reported in some users

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