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Lancet 383(9911):3139 Tabernero J et al (2015) Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study

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The overall safety and tolerability profile of orforglipron in ATTAIN-MAINTAIN was consistent with previous orforglipron Phase 3 studies

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The excipients, buffers, and preservatives in each pen are identical batch to batch, tested extensively for stability at various temperatures

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doi: 10.1172/JCI143777 61 HeM.WeiW.ZhangY.XiangZ.PengD.KasimumaliA.et al

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