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Phase 2 trial (Lancet 2021) tested cagrilintide 0.3 mg through 4.5 mg/week as monotherapy and reported a clear dose-response, with 10.8% mean weight loss at 4.5 mg/week at 26 weeks
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Notably, participants consumed inadequate calories from carbohydrates, adequate calories from protein as a percentage of total calories (though critically insufficient in g/kg/day for muscle preservation), and excess calories from fat
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