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Going from tirzepatide to semaglutide often produces more noticeable fatigue because you are losing the GIP component that may have been contributing to energy levels
That small change might make all the difference in keeping your weight loss journey smooth and sustainable
EAT GLP-1R and GIP-R activation can induce a beneficial balance between increased adipogenesis and reduced ectopic fat accumulation
Onofrj M, et al
