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Researchers using the combination should be aware of this potential effect, particularly at higher retatrutide doses

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Stronger barrier function reduces transepidermal water loss and helps skin maintain its moisture content

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Because they work differently, clinicians often combine them when a single medication isnt enough or when a broader set of goals is being considered

This extended trial period (versus typical 30-60 day windows) acknowledges that tissue repair processes are gradual and that fair assessment requires adequate time