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When water intake drops while the medication simultaneously slows digestion and allows more water absorption from stool, constipation becomes almost inevitable without conscious effort to stay hydrated

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In the recently published BARI-OPTIMISE double-blind, placebo-controlled trial, 70 patients post-SG or RYGB who were tested and found to have insufficient GLP-1 response to meal stimulation were randomized to receive liraglutide (3 mg/day) or placebo, in addition to lifestyle interventions [49]

Pola P, Savi M, Grilli M, and et al

Kluwer Academic Publishers, 237-262, 2002