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Introducing highly fermentable prebiotics into a gut that is currently overgrown with pathogenic or histamine-producing bacteria can trigger a "flare-up." The harmful bacteria will rapidly ferment the new fiber, producing excess gas, LPS, and histamine, which can temporarily worsen leaky gut and provoke a severe mast cell reaction
Moreover, there have been hypoglycemic agents such as SGLT-is have been proven to have direct renal benefits independent of glucose
Dietary curcumin supplementation attenuates hepatic damage and function abnormality in a chronic corticosterone-induced stress model in broilers
Factors such as appetite changes, gastrointestinal tolerance, energy levels, and overall progress are monitored closely
2018 Oct 1 [cited 2025 Apr 11];39(5):719
Theoretical concerns with chronic high-dose use include organ enlargement and exacerbation of active malignancy via IGF-1 axis growth signaling
