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SOD is the main antioxidant enzyme that eliminates the first product of one-electron reduction of molecular oxygen (O 2 - )

Characterization of the stress-inducing effects of homocysteine

It was demonstrated that N-Hcy-Lys was elevated in patients with acute myocardial infarction and its level was correlated with plasma asymmetric dimethylarginine, the endogenous inhibitor of endothelial nitric oxide synthase 10,11

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But instead of producing a single change, berberine interacts with multiple targets, impacting more than one disease at a time

Luckily, a lot of works about assessing the potential PDA risk of every antidiabetic drug were done previously