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Long-term effects on insulin sensitivity remain under investigation

In severe cases, obesity itself can lead to obesity-induced lymphedema , a condition increasingly recognized by lymphatic specialists

Indeed, genetic deficiency of the translocase markedly reduced the mitochondrial acetylcarnitine-dependent nuclear histone acetylation, indicating the significance of the carnitine-dependent mitochondrial acetyl group contribution to histone acetylation

Low body temperature

BBR demonstrates robust anti-obesity effects in both preclinical and clinical settings [4, 47, 175, 222, 223]

ECG, physical exam, neurological assessments, and markers (NfL, p-tau 181, GFAP, hs-CRP) at week 52, 104, 156