The most frequent adverse events were mainly mild-to-moderate gastrointestinal events, which reduced over time."The magnitude of weight loss observed with retatrutide has the potential to slow disease progression and reshape how we treat and manage type 2 diabetes," Bajaj said in a statement.Several authors disclosed ties to biopharmaceutical companies, including Eli Lilly, which is developing retatrutide and funded the study.Abstract/Full Text (subscription or payment may be required)More Information.Sign up for our weekly HealthDay newsletter
Certain health conditions, physiological states, or expectations may increase risk or limit safety
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It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients
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