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The simultaneous activation of GIP and GLP-1 receptors may have central synergistic effects on appetite control, greater than selective GLP-1 receptor agonists [55], although preliminary studies do not support this hypothesis [56]

Ann Transl Med 2018

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Although the exact etiology remains unclear, both UC and CD are thought to result from uncontrolled inflammation and immune dysregulation in genetically predisposed individuals [213]

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