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In: Proceedings of international conference on life Science and Technology

Of 18 SLE patients on GLP-1 medications, only one experienced a mild-to-moderate flare during follow-up

In a New York Times opinion column explaining why the FDA is taking action this week, Commissioner Marty Makary highlighted online pharmacies marketing drugs without presenting an adequate balance of risks, and in particular a Super Bowl ad from Hims & Hers parading the benefits of GLP-1 drugs without any mention of side effects. But the compounding letters scope is narrower than that messaging suggests

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It appears to represent a recalibration of the brain's reward and satiety circuitry, reducing the hedonic drive to eat independently of hunger signals

In a word, GLP-1R can exert glucose-lowering effects through multiple mechanisms