A further mechanistic consideration is whether the pomegranate extract may have influenced plasma TMAO concentrations partly through its effect on the absorption of L-carnitine in the small intestine, rather than solely through inhibition of microbial TMA production
And when something tastes good, consistency follows - which is the real engine behind visible change
Sources: InfantRisk Center: Krutsch, K
More elegantly, the peptide itself can be redesigned for stability unnatural amino acids (like Aib), cyclization, D-amino acid substitutions, and PEGylation all make the molecule harder for proteases to cleave and can extend half-life
The figure also shows an acetylated lipoyllysine moiety, highlighting its role in acyl group transfer
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