For the ITT sample, all randomized participants were used for the analyses except for those who withdrew or were lost to follow-up
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These liver detoxification pathways depend on coordinated Phase I transformation, Phase II conjugation and Phase III transport, together with adequate methylation, homocysteine metabolism, transsulfuration, glutathione, taurine and other sulfur compounds
N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells
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Claims to the contrary can generally be discounted as due to artifacts, e.g., homo- or hetero-exchange with intracellular amino acids