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Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

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Neither compound has established long-term human safety data

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The Orbitrap Astral was operated in data-independent acquisition (DIA) mode, with MS1 scans acquired in the Orbitrap at a resolution of 240,000, with a maximum injection time of 5 ms over a range of 380980 m/z

The transcriptional activity of Nrf2 is also based on the level of this molecule phosphorylation 68