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Individuals who may be at greater risk include: Those with a pre-existing diagnosis of osteoarthritis, rheumatoid arthritis, or other inflammatory joint conditions Patients with obesity-related joint loading, particularly affecting the knees, hips, and lower back Older adults, in whom musculoskeletal complaints are more prevalent at baseline Individuals experiencing rapid weight loss, which may transiently alter joint mechanics and gait, particularly in the lower limbs this is a theoretical consideration based on general musculoskeletal principles rather than retatrutide-specific evidence Significant weight reduction one of retatrutide's primary therapeutic effects is generally associated with reduced mechanical load on weight-bearing joints , which may improve joint symptoms over time in individuals with obesity-related arthropathy

A few months after the studys publication, the Food and Drug Administration approved Wegovy for the treatment of MASH in adults with moderate-to-advanced scarring, making it the second approved treatment option for the liver condition, which is increasing in prevalence

These pleiotropic effects reinforce their clinical positioning but also highlight the complexity of their pharmacodynamic profile

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Advances in the study of S100A9 in cardiovascular diseases