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A pivotal 2007 study published in the Journal of Physiology and Pharmacology examined rats with experimentally induced esophagitis and sphincter failure
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However, during APAP overdose, the excessive production of NAPQI overwhelms the cellular antioxidant capacity, leading to the accumulation of NAPQI-protein adducts
Curr Protoc 1:e196 Ravi V, Mishra S, Sundaresan NR (2021b) Chapter 16 - Role of sirtuins in cardiovascular diseases
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