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Ethics declarations Competing interests DD received an honorarium/advisory fee from: Novonordisk, Lilly, Boehringer Ingelheim

In mice, inactivation of NLRP3 or inflammasome signaling suppresses inflammation and fibrosis in models of NASH (173, 174) and alcoholic steatohepatitis (175) by reducing recruitment and activation of Kupffer cells (174)

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4.1 Limitations of the current literature Although research examining the combined and comparative effects of GLP-1 receptor agonists and exercise is rapidly expanding, several limitations constrain the current evidence base

Trimethylamine N-oxide: a harmful, protective or diagnostic marker in lifestyle diseases