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That study will provide insights into the potential of GLP-1 RAs to modify the disease course in HFpEF patients
However, due to the lack of regulation , potential side effects , and the risk of misuse , it should be approached with caution
Summary: GLP-1 receptor agonists can modestly reduce systolic blood pressure by approximately 24 mmHg, though they are not licensed specifically as antihypertensive medications in the UK
Cardiovasc Drugs Ther (2014) 28(5):42532.10.1007/s10557-014-6539-4 89 GonalvesAMarquesCLealERibeiroCFReisFAmbrsioAFet alDipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats
In this framework, the novel dual GIP and GLP-1 receptor agonist tirzepatide seems to be not just a new antidiabetic medication
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