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The best choice between Cagrilintide vs Retatrutide ultimately comes down to individual health needs, tolerance for side effects, and long-term goals
In the REDEFINE 2 study (about 1206 adults with type 2 diabetes and overweight/obesity, 68 weeks), the combination produced a weight reduction of 15.7% versus 3.1% in the placebo group, with a significant improvement in glycemic control
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For weight management , NICE technology appraisals TA875 (semaglutide 2.4mg, Wegovy) and TA664 (liraglutide 3.0mg, Saxenda) specify different continuation criteria and require specialist service involvement
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