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Long-term adherence is essential to realizing the full therapeutic potential of GLP-1s, yet behavioral factors (such as reaching personal weight goals or perceived social stigma) and systemic issues (like high out-of-pocket costs and fragmented care) disproportionately affect obesity patients
Nationwide, high out-of-pocket (OOP) drug costs have impeded access to GLP-1 medications for many people
It shows how FDAs stance has progressed from exploratory discussion (20222024) to concrete enforcement (20252026)
The mean changes from baseline to Week 26 were -0.4 kg, -2.4 kg and -3.7 kg in the placebo, semaglutide tablets 7 mg and semaglutide tablets 14 mg arms, respectively
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Clinical trials demonstrated that higher doses generally produced greater weight loss, but they also carried an increased risk of adverse effects
