The type I error rate was strongly controlled within each estimand independently for evaluation of the primary and key secondary end points with a graphical approach
Without them, any regained weight is more likely to come back as fat, not lean, performance-driven muscle
Reduced cardiovascular risk : Research suggests that semaglutide may lower the risk of cardiovascular events, such as heart attacks and strokes, by improving blood sugar control and promoting weight loss
Available in extended-release and immediate-release versions, Metformin also contributes modest weight reduction or, at a minimum, weight neutrality
However, the research also indicated that the compound had a relatively short half-life in the body, meaning it broke down quickly and required frequent administration
DOI: 10.1056/NEJMoa2501006