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Its prevalence continues to rise due to aging populations, smoking, and worsening air pollution

However, when emodin, rhein and to a lesser extent cis -stilbene, were used in combination with each topoisomerase II inhibitor, there was an antagonistic increase in ATP, an inhibition of apoptosis and no cell-cycle arrest

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44 Pyroptosis has been reported as a significant mechanism of cell death in APAP-induced liver injury, involving activation of the NLRP3 inflammasome and subsequent caspase-1 activation

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