CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]
Ozempic is approved to manage Type 2 diabetes, reduce the risk of heart attacks and strokes in people with heart disease, and reduce the risk of worsening kidney disease
Improved Metabolic Health and Inflammation Balance Semaglutide has been shown to improve insulin resistance and metabolic markers
doi: 10.1172/JCI24422 65 HaeberleHATakizawaRCasolaABrasierARDieterichHJvan RooijenNet al
GLP-1 injectables may be considered when you meet BMI criteria (typically 30 or higher, or 27 or higher with weight-related health conditions), you are comfortable with weekly self-injection, and your health profile does not include contraindications for GLP-1 medications
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