once-weekly semaglutide in adults with overweight or obesity pubmed Two-year effects of obesity: the STEP 5 trial Efficacy and safety of once-weekly

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Conventional therapies targeting classical risk factors, such as hypertension, diabetes mellitus, and dyslipidemia, confer partial protective effects but do not completely halt DKD progression or sufficiently mitigate its associated cardiovascular risk [6]

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The tirzepatide and testosterone combination is particularly popular because tirzepatide provides stronger weight loss than semaglutide, and the dual receptor mechanism may better preserve lean mass